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Studies & Clinical Trials

Our foundational work with Harvard Medical School and other leading institutions demonstrates our deep expertise and a commitment to producing leading academic research in our field.


We strive to advance the study and practice of Restorative Health Sciences and
the promotion of universal access to an improved quality of life. 


4.  PainQx AI-Powered EEG Analysis

    for Objective Pain Assessment

The PainQx platform is an AI-powered cloud-based solution that operates on electroencephalographic (EEG) data collected from a patient, processing the data through proprietary algorithms and providing a classification of the patient’s pain state to the clinician at the point of care. PainQx provides an initial classification of a patient’s pain state and supports patient follow-up to help assess treatment efficacy. It also supports chronic pain assessment in populations that can't accurately articulate or express pain, such as patients with Alzhiemer’s.

Lumeo Chronic Pain Modular Program
Stellate Ganglion Blocks for PTSD & Opiod Dependency
AI-Powered EEG Analysis
Image by Chris Liverani

2.   Lumeo Chronic Pain

    Modular Program 

Utilizing best available evidence, Lumeo has designed an orchestrated, curated interactive web-based program focused on providing multidimensional pain care with the goal of improving quality of life and facilitating a return to more meaningful daily activities for patients, and reducing unhelpful medical interventions and costs.

3.  Stellate Ganglion Blocks for PTSD 

Our proposed research study measures the effects of a novel application of an already accepted intervention. If effective this would become standard of care in conjunction with existing behavioral therapy programs, but have the advantage of an immediate effect on the patient's sense of wellbeing and ability to resist intrusive thoughts and impulsive behavior.

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1.   Ketamine Virtual Reality Therapy 

KVR is the use of virtual reality video and audio stimulation to enhance the therapeutic experience that the ketamine treatment provides patients. Dr. Canty and Comprehensive Spine and Pain Center of NY have pioneered this treatment combination for the treatment of chronic pain and depression. We have conducted the first research analysis of its effects in this patient population and the results have been very promising.


Selected Publications


2.  Canty T.  Neuromodulation.  in: Sackheim K, (ed)  Pain Management Clinical Pocket Guide.  Springer, New York, 2014.

Spinal cord stimulation is an advanced interventional pain management therapy. By implanting electrodes, impulses can be directed at adjacent nervous structures within both the central and peripheral nervous system to modulate pain sensation. Proper patient selection and lead placement are paramount to obtaining high success rates and pain relief. This chapter details the process of selecting ideal candidates, the trial and permanent implantation techniques, and patient management postoperatively.


3.  Raju S, Canty T: Regional Anesthesia in the Obese Patient, in Weiner-Kronish K, Ortiz V (eds) Perioperative Anesthesia for the Obese Patient. Informa HealthCare, 2009. 

Cutting-edge, in-depth coverage of the links between obesity and anesthesia in surgery, the reader-friendly Handbook of Perioperative Anesthesia: Complications and Challenges of the Obese Patient guides the practicing anesthesiologist through each stage of surgery for the obese patient.  


1.  Selinger, M. , Compton, D. , Morris, H. and Canty, T. (2023) Virtual Reality as an Adjunct to Ketamine Infusion Therapy Increases Patient Satisfaction in the Management of Chronic Pain and Depression: A Retrospective Pilot Study. Journal of Behavioral and Brain Science, 13, 243-261

The management of patients with concomitant chronic pain (CP) and Major Depressive Disorder (MDD) remains challenging for clinicians. Current chronic pharmacologic management is often unsuccessful, or has intolerable side effects to the patients. While not restricted to patients with chronic pain, these patients are often diagnosed with depression, presenting with symptoms such as poor mood, anhedonia, and altered cognitive processes. It is estimated that a substantial proportion of treated patients do not derive a substantive benefit from traditional pharmacological treatments for depression. The present study involved a retrospective review of cases, exploring the patient-reported satisfaction with and tolerability of a novel use of virtual reality (VR), coined KVR, as an adjunct to intravenous ketamine infusion therapies.

Selected Publications

4.  Canty T, Balantyne J:  Postoperative pain therapy, in Pedersen T, Møller AM (eds) Evidence-based Anaesthesia, Cambridge, UK, Cambridge University Press. 2006.

This chapter reviews alternative and adjunctive modes of delivering postoperative analgesia, and summarizes what is known about efficacy and outcome. It presents the evidence for the commonly utilized analgesic modalities as they pertain to postoperative outcome in light of our overall goal of rapid return to normal physiologic function after surgery and the increasing movement towards a multimodal approach to analgesia. 


5.  Tolba R., Fontenot A. (2019) Intercostal Nerve Block. In: Deer T., Pope J., Lamer T., Provenzano D. (eds) Deer's Treatment of Pain. Springer, Cham. 

The intercostal nerve block is an attractive option for clinicians and patients alike as it is a technically simple block to perform and provides effective analgesia in patients with thoracic and upper abdominal pain. While it is associated with its own risks of complications including pneumothorax, hematoma, and local anesthetic toxicity, these risks tend to occur rarely and can be further reduced with operator experience and utilization of image guidance. In the appropriate patient population, intercostal nerve blocks can be utilized, in conjunction with general anesthesia, to improve postoperative pain control, hasten recovery, and improve overall outcomes and patient satisfaction.


6.  Case of glioblastoma patient treated with tumor treating fields therapy at recurrence degenerating to sarcoma. Majd P, O’Connell DE, Kim RC, Bota DA, Carrillo JA. CNS Oncology. 2017 Apr;6(20):89-94.

Optune® treatment is a US FDA-approved treatment for glioblastoma (GBM) that employs alternating electric fields. Tumor treating field (TTF) therapy can exert its effects on GBM via cell cycle mitosis disruption and cytokinesis. We describe a patient with recurrent GBM who had disease progression following standard surgical treatment and concomitant chemoradiotherapy, and was found to have sarcomatous transformation after initiation of TTF therapy with bevacizumab. 


7.  First report of tumor treating fields use in combination with bevacizumab in a pediatric patient: a case report. DE O'Connell, V Shen, W Loudon, and DA Bota. CNS Oncology. 2017 Jan;6(1):11-18.

We report the first case of a pediatric patient with glioblastoma (GBM; WHO grade IV astrocytoma) successfully treated with tumor treating fields (TTF). The patient was diagnosed with GBM when 13 years of age and progressed through surgical resection, radiotherapy and chemotherapy. 


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